1QW7

Structure of an Engineered Organophosphorous Hydrolase with Increased Activity Toward Hydrolysis of Phosphothiolate Bonds

Summary for 1QW7

• Entry DOI: 10.2210/pdb1qw7/pdb
• Related: 1DPM
• Descriptor: Parathion hydrolase, COBALT (II) ION, SODIUM ION, ... (5 entities in total)
• Functional Keywords: organophosphorous hydrolase, phosphotriesterase, vx, rvx, 4-methylbenzylphosphonate, mutant, hydrolase
• Biological source: Brevundimonas diminuta
• Cellular location: Cell membrane; Peripheral membrane protein: P0A434
• Total number of polymer chains: 2
• Total formula weight: 73555.11

Authors

Mesecar, A.D.,Grimsley, J.K.,Holton, T.,Wild, J.R. (deposition date: 2003-09-01, release date: 2004-11-30, Last modification date: 2023-11-15)

• Primary citation: Grimsley, J.K.,Calamini, B.,Wild, J.R.,Mesecar, A.D.; Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site.; Arch.Biochem.Biophys., 442:169-179, 2005; PubMed: 16188223; DOI: 10.1016/j.abb.2005.08.012

Experimental method

X-RAY DIFFRACTION (1.9 Å)