1QUV

CRYSTAL STRUCTURE OF THE RNA DIRECTED RNA POLYMERASE OF HEPATITIS C VIRUS

Summary for 1QUV

• Entry DOI: 10.2210/pdb1quv/pdb
• Descriptor: PROTEIN (RNA-DIRECTED RNA POLYMERASE) (2 entities in total)
• Functional Keywords: rna dependent rna polymerase, replicase, hcv, ns5b, transferase
• Biological source: Hepatitis C virus
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• Total number of polymer chains: 1
• Total formula weight: 64247.60

Authors

Ago, H.,Miyano, M.,Adachi, T.,Habuka, N. (deposition date: 1999-07-04, release date: 1999-11-05, Last modification date: 2024-02-14)

• Primary citation: Ago, H.,Adachi, T.,Yoshida, A.,Yamamoto, M.,Habuka, N.,Yatsunami, K.,Miyano, M.; Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.; Structure Fold.Des., 7:1417-1426, 1999; PubMed: 10574802; DOI: 10.1016/S0969-2126(00)80031-3

Experimental method

X-RAY DIFFRACTION (2.5 Å)