1QS4

Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone

Summary for 1QS4

Entry DOI	10.2210/pdb1qs4/pdb
Descriptor	PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49)), MAGNESIUM ION, 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE, ... (4 entities in total)
Functional Keywords	dna integration, integrase, hiv, aspartyl protease, endonuclease, transferase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	3
Total formula weight	50802.25
Authors	Goldgur, Y.,Craigie, R.,Fujiwara, T.,Yoshinaga, T.,Davies, D.R. (deposition date: 1999-06-25, release date: 1999-11-17, Last modification date: 2024-02-14)
Primary citation	Goldgur, Y.,Craigie, R.,Cohen, G.H.,Fujiwara, T.,Yoshinaga, T.,Fujishita, T.,Sugimoto, H.,Endo, T.,Murai, H.,Davies, D.R. Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc.Natl.Acad.Sci.USA, 96:13040-13043, 1999 Cited by PubMed: 10557269 DOI: 10.1073/pnas.96.23.13040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation