1QJ6

Novel Covalent Active Site Thrombin Inhibitors

1QJ6 の概要

• エントリーDOI: 10.2210/pdb1qj6/pdb
• 関連するPDBエントリー: 1QJ1 1QJ7
• 分子名称: THROMBIN, HIRUGEN, 6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID, ... (5 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, blood coagulation-inhibitor complex, proteinase, blood coagulation, trypsin like proteinase, protease-inhibitor complex, hydrolase- hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35636.63

構造登録者

Jhoti, H.,Cleasby, A. (登録日: 1999-06-22, 公開日: 2000-06-22, 最終更新日: 2018-05-30)

• 主引用文献: Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.,Weir, M.,Wonacott, A.; Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template; Biochemistry, 38:7969-, 1999; PubMed: 10387040; DOI: 10.1021/BI9830359

実験手法

X-RAY DIFFRACTION (2.2 Å)