1QJ1

Novel Covalent Active Site Thrombin Inhibitors

Summary for 1QJ1

• Entry DOI: 10.2210/pdb1qj1/pdb
• Related: 1QJ6 1QJ7
• Descriptor: THROMBIN, HIRUGEN, 6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID, ... (5 entities in total)
• Functional Keywords: blood coagulation-inhibitor, proteinase, trypsin like proteinase, protease-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35622.60

Authors

Jhoti, H.,Cleasby, A. (deposition date: 1999-06-21, release date: 2000-06-22, Last modification date: 2018-05-30)

• Primary citation: Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.,Weir, M.,Wonacott, A.; Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template; Biochemistry, 38:7969-, 1999; PubMed: 10387040; DOI: 10.1021/BI9830359

Experimental method

X-RAY DIFFRACTION (2 Å)