1QHR

NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS

1QHR の概要

• エントリーDOI: 10.2210/pdb1qhr/pdb
• 分子名称: ALPHA THROMBIN, HIRUGEN, 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE, ... (5 entities in total)
• 機能のキーワード: proteinase, blood coagulation, trypsin like proteinase, complex (serine protease-inhibitor), blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35466.47

構造登録者

Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.,Wonacott, A. (登録日: 1999-05-26, 公開日: 2000-05-31, 最終更新日: 2023-12-27)

• 主引用文献: Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.J.,Weir, M.,Wonacott, A.; Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.; Biochemistry, 38:7969-7977, 1999; PubMed: 10387040; DOI: 10.1021/bi9830359

実験手法

X-RAY DIFFRACTION (2.2 Å)