1QHR

NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS

Summary for 1QHR

Entry DOI	10.2210/pdb1qhr/pdb
Descriptor	ALPHA THROMBIN, HIRUGEN, 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE, ... (5 entities in total)
Functional Keywords	proteinase, blood coagulation, trypsin like proteinase, complex (serine protease-inhibitor), blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734
Total number of polymer chains	3
Total formula weight	35466.47
Authors	Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.,Wonacott, A. (deposition date: 1999-05-26, release date: 2000-05-31, Last modification date: 2023-12-27)
Primary citation	Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.J.,Weir, M.,Wonacott, A. Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template. Biochemistry, 38:7969-7977, 1999 Cited by PubMed: 10387040 DOI: 10.1021/bi9830359 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation