1QHI

HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE

Summary for 1QHI

Entry DOI	10.2210/pdb1qhi/pdb
Descriptor	PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE, ... (4 entities in total)
Functional Keywords	transferase, transferase (phosphotransferase) thymidine, transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae novel inhibitor
Biological source	Herpes simplex virus (type 1 / strain 17)
Total number of polymer chains	2
Total formula weight	80569.97
Authors	Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R. (deposition date: 1999-05-12, release date: 1999-07-09, Last modification date: 2023-08-16)
Primary citation	Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R. Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir. FEBS Lett., 443:121-125, 1999 Cited by PubMed: 9989588 DOI: 10.1016/S0014-5793(98)01619-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation