1Q6T

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 11

Summary for 1Q6T

• Entry DOI: 10.2210/pdb1q6t/pdb
• Related: 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S
• Descriptor: Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, 6-[4-((2S)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL]-2-[(1S)-1-METHOXY-3-METHYLBUTYL]QUINOLIN-8-YLPHOSPHONIC ACID, ... (4 entities in total)
• Functional Keywords: phosphatase, secondary binding site, selectivity, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 2
• Total formula weight: 74178.48

Authors

Scapin, G.,Patel, S.B.,Becker, J.W.,Wang, Q.,Desponts, C.,Waddleton, D.,Skorey, K.,Cromlish, W.,Bayly, C.,Therien, M.,Gauthier, J.Y.,Li, C.S.,Lau, C.K.,Ramachandran, C.,Kennedy, B.P.,Asante-Appiah, E. (deposition date: 2003-08-13, release date: 2003-09-30, Last modification date: 2023-08-16)

• Primary citation: Scapin, G.,Patel, S.B.,Becker, J.W.,Wang, Q.,Desponts, C.,Waddleton, D.,Skorey, K.,Cromlish, W.,Bayly, C.,Therien, M.,Gauthier, J.Y.,Li, C.S.,Lau, C.K.,Ramachandran, C.,Kennedy, B.P.,Asante-Appiah, E.; The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B; Biochemistry, 42:11451-11459, 2003; PubMed: 14516196; DOI: 10.1021/bi035098j

Experimental method

X-RAY DIFFRACTION (2.3 Å)