1Q4G

2.0 Angstrom Crystal Structure of Ovine Prostaglandin H2 Synthase-1, in complex with alpha-methyl-4-biphenylacetic acid

Summary for 1Q4G

• Entry DOI: 10.2210/pdb1q4g/pdb
• Related: 1CQE 1EQG 1EQH 1HT5 1HT8 1PRH
• Descriptor: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: cyclooxygenase, non-steroidal anti-inflammatory drug, peroxidase, prostaglandin synthase, egf-like domain, membrane binding domain, oxidoreductase
• Biological source: Ovis aries (sheep)
• Total number of polymer chains: 2
• Total formula weight: 136101.03

Authors

Gupta, K.,Selinksy, B.S.,Kaub, C.J.,Katz, A.K.,Loll, P.J. (deposition date: 2003-08-03, release date: 2004-01-06, Last modification date: 2023-08-16)

• Primary citation: Gupta, K.,Selinsky, B.S.,Kaub, C.J.,Katz, A.K.,Loll, P.J.; The 2.0A Resolution Crystal Structure of Prostaglandin H(2) Synthase-1: Structural Insights into an Unusual Peroxidase; J.Mol.Biol., 335:503-518, 2004; PubMed: 14672659; DOI: 10.1016/j.jmb.2003.10.073

Experimental method

X-RAY DIFFRACTION (2 Å)