1PYY

Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution

Summary for 1PYY

Entry DOI	10.2210/pdb1pyy/pdb
Related	1K25 1PMD 1QME 1QMF
Related PRD ID	PRD_900045
Descriptor	Penicillin-binding protein 2X, 6-O-octanoyl-beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, SULFATE ION, ... (5 entities in total)
Functional Keywords	penicillin-binding protein, antibiotic resistance, peptidoglycan synthesis, cell wall, transmembrane, transpeptidase
Biological source	Streptococcus pneumoniae
Cellular location	Cell membrane; Single-pass membrane protein: P59676
Total number of polymer chains	1
Total formula weight	77476.65
Authors	Chesnel, L.,Pernot, L.,Lemaire, D.,Champelovier, D.,Croize, J.,Dideberg, O.,Vernet, T.,Zapun, A. (deposition date: 2003-07-09, release date: 2003-09-30, Last modification date: 2023-08-16)
Primary citation	Chesnel, L.,Pernot, L.,Lemaire, D.,Champelovier, D.,Croize, J.,Dideberg, O.,Vernet, T.,Zapun, A. The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains J.Biol.Chem., 278:44448-44456, 2003 Cited by PubMed: 12923202 DOI: 10.1074/jbc.M305948200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation