1PWL

Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat

Summary for 1PWL

Entry DOI	10.2210/pdb1pwl/pdb
Related	1PWM
Descriptor	aldose reductase, 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	aldose reductase, atomic resolution, ternary complex, inhibitor binding, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37090.95
Authors	El-Kabbani, O.,Darmanin, C.,Schneider, T.R.,Hazemann, I.,Ruiz, F.,Oka, M.,Joachimiak, A.,Schulze-Briese, C.,Tomizaki, T.,Mitschler, A.,Podjarny, A. (deposition date: 2003-07-02, release date: 2004-02-24, Last modification date: 2024-04-03)
Primary citation	El-Kabbani, O.,Darmanin, C.,Schneider, T.R.,Hazemann, I.,Ruiz, F.,Oka, M.,Joachimiak, A.,Schulze-Briese, C.,Tomizaki, T.,Mitschler, A.,Podjarny, A. Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors PROTEINS, 55:805-813, 2004 Cited by PubMed: 15146479 DOI: 10.1002/prot.20001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation