1PTY
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES
Summary for 1PTY
| Entry DOI | 10.2210/pdb1pty/pdb |
| Descriptor | PROTEIN TYROSINE PHOSPHATASE 1B, MAGNESIUM ION, O-PHOSPHOTYROSINE, ... (4 entities in total) |
| Functional Keywords | hydrolase, acetylation, phosphorylation, inhibition |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
| Total number of polymer chains | 1 |
| Total formula weight | 37896.22 |
| Authors | Zhao, Y.,Puius, Y.A.,Sullivan, M.,Lawrence, D.,Almo, S.C.,Zhang, Z.-Y. (deposition date: 1997-01-16, release date: 1998-01-21, Last modification date: 2024-02-21) |
| Primary citation | Puius, Y.A.,Zhao, Y.,Sullivan, M.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94:13420-13425, 1997 Cited by PubMed: 9391040DOI: 10.1073/pnas.94.25.13420 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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