1PME

STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE

Summary for 1PME

• Entry DOI: 10.2210/pdb1pme/pdb
• Descriptor: ERK2, SULFATE ION, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, ... (4 entities in total)
• Functional Keywords: map kinase, serine/threonine protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P28482
• Total number of polymer chains: 1
• Total formula weight: 44089.60

Authors

Xie, X. (deposition date: 1998-06-08, release date: 1999-06-08, Last modification date: 2022-12-21)

• Primary citation: Fox, T.,Coll, J.T.,Xie, X.,Ford, P.J.,Germann, U.A.,Porter, M.D.,Pazhanisamy, S.,Fleming, M.A.,Galullo, V.,Su, M.S.,Wilson, K.P.; A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase.; Protein Sci., 7:2249-2255, 1998; PubMed: 9827991

Experimental method

X-RAY DIFFRACTION (2 Å)