1PGZ

Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)

Summary for 1PGZ

• Entry DOI: 10.2210/pdb1pgz/pdb
• Descriptor: 5'-D(*T*TP*AP*GP*GP*GP*TP*TP*AP*GP*(6MI)P*G)-3', Heterogeneous nuclear ribonucleoprotein A1 (3 entities in total)
• Functional Keywords: protein-dna complex; up1; human telomeric repeat; htr; tr2-11f; rrm; rna recognition motif; 6-mi; 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine; hnrnp a1, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P09651
• Total number of polymer chains: 2
• Total formula weight: 25987.39

Authors

Myers, J.C.,Moore, S.A.,Shamoo, Y. (deposition date: 2003-05-28, release date: 2003-11-11, Last modification date: 2023-08-16)

• Primary citation: Myers, J.C.,Moore, S.A.,Shamoo, Y.; Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures; J.Biol.Chem., 278:42300-42306, 2003; PubMed: 12904298; DOI: 10.1074/jbc.M306147200

Experimental method

X-RAY DIFFRACTION (2.6 Å)