1PGF

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL

1PGF の概要

• エントリーDOI: 10.2210/pdb1pgf/pdb
• 分子名称: PROSTAGLANDIN H2 SYNTHASE-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, dioxygenase, peroxidase
• 由来する生物種: Ovis aries (sheep)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 136194.71

構造登録者

Loll, P.J.,Picot, D.,Garavito, R.M. (登録日: 1995-12-02, 公開日: 1997-01-11, 最終更新日: 2020-07-29)

• 主引用文献: Loll, P.J.,Picot, D.,Ekabo, O.,Garavito, R.M.; Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.; Biochemistry, 35:7330-7340, 1996; PubMed: 8652509; DOI: 10.1021/bi952776w

実験手法

X-RAY DIFFRACTION (4.5 Å)