1PCG

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

Summary for 1PCG

Entry DOI	10.2210/pdb1pcg/pdb
Descriptor	estrogen receptor, peptide inhibitor, ESTRADIOL, ... (4 entities in total)
Functional Keywords	co-activator binding site, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
Total number of polymer chains	4
Total formula weight	58362.82
Authors	Leduc, A.M.,Trent, J.O.,Wittliff, J.L.,Bramlett, K.S.,Briggs, S.L.,Chirgadze, N.Y.,Wang, Y.,Burris, T.P.,Spatola, A.F. (deposition date: 2003-05-16, release date: 2003-10-28, Last modification date: 2021-10-27)
Primary citation	Leduc, A.M.,Trent, J.O.,Wittliff, J.L.,Bramlett, K.S.,Briggs, S.L.,Chirgadze, N.Y.,Wang, Y.,Burris, T.P.,Spatola, A.F. Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions Proc.Natl.Acad.Sci.USA, 100:11273-11278, 2003 Cited by PubMed: 13679575 DOI: 10.1073/pnas.1934759100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation