1P8J

CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN

1P8J の概要

• エントリーDOI: 10.2210/pdb1p8j/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000278
• 分子名称: Furin precursor, DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE INHIBITOR, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: prohormone convertase, spc1, pace, p-domain, chloromethylketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 426622.72

構造登録者

Henrich, S.,Cameron, A.,Bourenkov, G.P.,Kiefersauer, R.,Huber, R.,Lindberg, I.,Bode, W.,Than, M.E. (登録日: 2003-05-07, 公開日: 2003-07-08, 最終更新日: 2020-07-29)

• 主引用文献: Henrich, S.,Cameron, A.,Bourenkov, G.P.,Kiefersauer, R.,Huber, R.,Lindberg, I.,Bode, W.,Than, M.E.; The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity; Nat.Struct.Biol., 10:520-526, 2003; PubMed: 12794637; DOI: 10.1038/nsb941

実験手法

X-RAY DIFFRACTION (2.6 Å)