1P4F

DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT

Summary for 1P4F

Entry DOI	10.2210/pdb1p4f/pdb
Related	1IG1 1JKK 1JKL 1JKS 1JKT
Descriptor	Death-associated protein kinase 1, 5,6-Dihydro-benzo[H]cinnolin-3-ylamine (3 entities in total)
Functional Keywords	transferase, kinase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	33862.42
Authors	Velentza, A.V.,Wainwright, M.S.,Zasadzki, M.,Mirzoeva, S.,Haiech, J.,Focia, P.J.,Egli, M.,Watterson, D.M. (deposition date: 2003-04-23, release date: 2004-09-28, Last modification date: 2023-08-16)
Primary citation	Velentza, A.V.,Wainwright, M.S.,Zasadzki, M.,Mirzoeva, S.,Schumacher, A.M.,Haiech, J.,Focia, P.J.,Egli, M.,Watterson, D.M. An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury. Bioorg.Med.Chem.Lett., 13:3465-3470, 2003 Cited by PubMed: 14505650 DOI: 10.1016/S0960-894X(03)00733-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation