1P2A

The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor

Summary for 1P2A

Entry DOI	10.2210/pdb1p2a/pdb
Related	1FVT
Descriptor	Cell division protein kinase 2, 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE (3 entities in total)
Functional Keywords	cyclin dependent kinase, naphthostyril oxindole, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34286.81
Authors	Liu, J.-J.,Dermatakis, A.,Lukacs, C.M.,Konzelmann, F.,Chen, Y.,Kammlott, U.,Depinto, W.,Yang, H.,Yin, X.,Chen, Y.,Schutt, A.,Simcox, M.E.,Luk, K.-C. (deposition date: 2003-04-15, release date: 2003-07-15, Last modification date: 2024-02-14)
Primary citation	Liu, J.-J.,Dermatakis, A.,Lukacs, C.M.,Konzelmann, F.,Chen, Y.,Kammlott, U.,Depinto, W.,Yang, H.,Yin, X.,Chen, Y.,Schutt, A.,Simcox, M.E.,Luk, K.-C. 3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors BIOORG.MED.CHEM., 13:2465-2468, 2003 Cited by PubMed: 12852944 DOI: 10.1016/S0960-894X(03)00488-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation