1OYT

COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR

Summary for 1OYT

• Entry DOI: 10.2210/pdb1oyt/pdb
• Related PRD ID: PRD_000481
• Descriptor: thrombin light chain, thrombin heavy chain, Hirudin IIB, ... (7 entities in total)
• Functional Keywords: serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28506
• Total number of polymer chains: 3
• Total formula weight: 35743.73

Authors

Banner, D.W.,Olsen, J.A. (deposition date: 2003-04-07, release date: 2003-06-24, Last modification date: 2024-04-03)

• Primary citation: Olsen, J.A.,Banner, D.W.,Seiler, P.,Obst-Sander, U.,D'Arcy, A.,Stihle, M.,Mueller, K.,Diederich, F.; A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF...C=O Interactions.; Angew.Chem.Int.Ed.Engl., 42:2507-2511, 2003; PubMed: 12800172; DOI: 10.1002/anie.200351268

Experimental method

X-RAY DIFFRACTION (1.67 Å)