1OYH

Crystal Structure of P13 Alanine Variant of Antithrombin

Summary for 1OYH

• Entry DOI: 10.2210/pdb1oyh/pdb
• Related: 1E04 1NQ9
• Descriptor: Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: thrombin; inhibition; heparin analogue; serine protease inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P01008 P01008
• Total number of polymer chains: 2
• Total formula weight: 100772.45

Authors

Johnson, D.J.D.,Huntington, J.A. (deposition date: 2003-04-04, release date: 2004-04-13, Last modification date: 2023-08-16)

• Primary citation: Johnson, D.J.D.,Huntington, J.A.; The influence of hinge region residue Glu-381 on antithrombin allostery and metastability; J.Biol.Chem., 279:4913-4921, 2004; PubMed: 14623882; DOI: 10.1074/jbc.M311644200

Experimental method

X-RAY DIFFRACTION (2.62 Å)