1OUK

The structure of p38 alpha in complex with a pyridinylimidazole inhibitor

Summary for 1OUK

• Entry DOI: 10.2210/pdb1ouk/pdb
• Related: 1M7Q
• Descriptor: Mitogen-activated protein kinase 14, SULFATE ION, 4-[5-[2-(1-PHENYL-ETHYLAMINO)-PYRIMIDIN-4-YL]-1-METHYL-4-(3-TRIFLUOROMETHYLPHENYL)-1H-IMIDAZOL-2-YL]-PIPERIDINE, ... (4 entities in total)
• Functional Keywords: map kinase, hydrophobic pocket, kinase domain, atp binding domain, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q16539
• Total number of polymer chains: 1
• Total formula weight: 42601.57

Authors

Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. (deposition date: 2003-03-24, release date: 2003-09-02, Last modification date: 2023-08-16)

• Primary citation: Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G.; Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity; Nat.Struct.Biol., 10:764-769, 2003; PubMed: 12897767; DOI: 10.1038/nsb949

Experimental method

X-RAY DIFFRACTION (2.5 Å)