1OT7

Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR

Summary for 1OT7

• Entry DOI: 10.2210/pdb1ot7/pdb
• Related: 1OSV
• Descriptor: Bile Acid Receptor, dodecamer peptide fragment of RPGR-interacting protein 1, 6-ETHYL-CHENODEOXYCHOLIC ACID, ... (5 entities in total)
• Functional Keywords: bile acid, nuclear receptor, coactivator, ligand binding domain, fxr, hormone-growth factor receptor complex, hormone/growth factor receptor
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Nucleus (Probable): Q62735
• Total number of polymer chains: 5
• Total formula weight: 58712.76

Authors

Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2003-03-21, release date: 2004-03-23, Last modification date: 2024-04-03)

• Primary citation: Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F.; Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR; Mol.Cell, 11:1093-1100, 2003; PubMed: 12718893; DOI: 10.1016/S1097-2765(03)00112-6

Experimental method

X-RAY DIFFRACTION (2.9 Å)