1OPH

NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN

1OPH の概要

• エントリーDOI: 10.2210/pdb1oph/pdb
• 関連するPDBエントリー: 1EJM 1OO8 1QLP
• 分子名称: Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor (3 entities in total)
• 機能のキーワード: serine proteinase inhibitor, michaelis-like complex, serpin, alpha-1 antitrypsin, trypsin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009; Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69704.98

構造登録者

Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. (登録日: 2003-03-05, 公開日: 2003-08-05, 最終更新日: 2023-08-16)

• 主引用文献: Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G.; Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases; J.Biol.Chem., 278:37881-37887, 2003; PubMed: 12860985; DOI: 10.1074/jbc.M305195200

実験手法

X-RAY DIFFRACTION (2.3 Å)