1OPH

NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN

Summary for 1OPH

• Entry DOI: 10.2210/pdb1oph/pdb
• Related: 1EJM 1OO8 1QLP
• Descriptor: Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor (3 entities in total)
• Functional Keywords: serine proteinase inhibitor, michaelis-like complex, serpin, alpha-1 antitrypsin, trypsin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009; Secreted, extracellular space: P00760
• Total number of polymer chains: 2
• Total formula weight: 69704.98

Authors

Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. (deposition date: 2003-03-05, release date: 2003-08-05, Last modification date: 2023-08-16)

• Primary citation: Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G.; Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases; J.Biol.Chem., 278:37881-37887, 2003; PubMed: 12860985; DOI: 10.1074/jbc.M305195200

Experimental method

X-RAY DIFFRACTION (2.3 Å)