1OO8
CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION
Summary for 1OO8
Entry DOI | 10.2210/pdb1oo8/pdb |
Descriptor | Alpha-1-antitrypsin precursor (2 entities in total) |
Functional Keywords | serpin, pittsburgh variant, hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 |
Total number of polymer chains | 1 |
Total formula weight | 44276.26 |
Authors | Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. (deposition date: 2003-03-03, release date: 2003-08-05, Last modification date: 2023-08-16) |
Primary citation | Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases J.Biol.Chem., 278:37881-37887, 2003 Cited by PubMed: 12860985DOI: 10.1074/jbc.M305195200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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