1OHR

VIRACEPT (R) (NELFINAVIR MESYLATE, AG1343): A POTENT ORALLY BIOAVAILABLE INHIBITOR OF HIV-1 PROTEASE

1OHR の概要

• エントリーDOI: 10.2210/pdb1ohr/pdb
• 分子名称: ASPARTYLPROTEASE, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE (3 entities in total)
• 機能のキーワード: aspartyl protease, hydrolase, hiv-i protease
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22175.29

構造登録者

Davies II, J.F. (登録日: 1997-09-27, 公開日: 1998-12-09, 最終更新日: 2024-02-14)

• 主引用文献: Kaldor, S.W.,Kalish, V.J.,Davies 2nd., J.F.,Shetty, B.V.,Fritz, J.E.,Appelt, K.,Burgess, J.A.,Campanale, K.M.,Chirgadze, N.Y.,Clawson, D.K.,Dressman, B.A.,Hatch, S.D.,Khalil, D.A.,Kosa, M.B.,Lubbehusen, P.P.,Muesing, M.A.,Patick, A.K.,Reich, S.H.,Su, K.S.,Tatlock, J.H.; Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.; J.Med.Chem., 40:3979-3985, 1997; PubMed: 9397180; DOI: 10.1021/jm9704098

実験手法

X-RAY DIFFRACTION (2.1 Å)