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1O2O

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

Summary for 1O2O
Entry DOI10.2210/pdb1o2o/pdb
Related1C5R
DescriptorBETA-TRYPSIN, CALCIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywordsserine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23802.79
Authors
Primary citationKatz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.-F.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W.
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
J.Mol.Biol., 329:93-120, 2003
Cited by
PubMed: 12742021
DOI: 10.1016/S0022-2836(03)00399-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

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