1O2H

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

1O2H の概要

• エントリーDOI: 10.2210/pdb1o2h/pdb
• 関連するPDBエントリー: 1C5R
• 分子名称: BETA-TRYPSIN, CALCIUM ION, 2-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-6-(CYCLOPENTYLOXY)BENZENOLATE, ... (4 entities in total)
• 機能のキーワード: serine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, hydrolase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23699.77

構造登録者

Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, W.F.,Hui, H.,Breitenbucher, G.,Allen, D.,Janc, J. (登録日: 2003-03-06, 公開日: 2003-05-13, 最終更新日: 2023-12-27)

• 主引用文献: Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.-F.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W.; Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors; J.Mol.Biol., 329:93-120, 2003; PubMed: 12742021; DOI: 10.1016/S0022-2836(03)00399-1

実験手法

X-RAY DIFFRACTION (1.77 Å)