1O0D

Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor

Summary for 1O0D

• Entry DOI: 10.2210/pdb1o0d/pdb
• Related: 1A5G 1NZQ 1PPB
• Related PRD ID: PRD_000480
• Descriptor: Thrombin light chain, Thrombin heavy chain, Decapeptide Hirudin Analogue, ... (5 entities in total)
• Functional Keywords: ternary complex; thrombin-active-site inhibitor-exo-site inhibitor, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35847.90

Authors

Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2003-02-21, release date: 2003-10-14, Last modification date: 2018-04-04)

• Primary citation: Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W.; D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety; Bioorg.Med.Chem.Lett., 13:2029-2033, 2003; PubMed: 12781189; DOI: 10.1016/S0960-894X(03)00236-1

Experimental method

X-RAY DIFFRACTION (2.44 Å)