1NUO

Two RTH Mutants with Impaired Hormone Binding

Summary for 1NUO

Entry DOI	10.2210/pdb1nuo/pdb
Descriptor	Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID (2 entities in total)
Functional Keywords	alpha helix, nuclear receptor, ligand binding domain, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10828
Total number of polymer chains	1
Total formula weight	30131.06
Authors	Huber, B.R.,Sandler, B.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Apriletti, J.W.,Baxter, J.D.,Fletterick, R.J. (deposition date: 2003-01-31, release date: 2003-04-15, Last modification date: 2024-04-03)
Primary citation	Huber, B.R.,Sandler, B.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Apriletti, J.W.,Baxter, J.D.,Fletterick, R.J. Two resistance to thyroid hormone mutants with impaired hormone binding Mol.Endocrinol., 17:643-652, 2003 Cited by PubMed: 12554782 DOI: 10.1210/me.2002-0095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation