1NR6

MICROSOMAL CYTOCHROME P450 2C5/3LVDH COMPLEX WITH DICLOFENAC

1NR6 の概要

• エントリーDOI: 10.2210/pdb1nr6/pdb
• 関連するPDBエントリー: 1DT6 1N6B
• 分子名称: CYTOCHROME P450 2C5, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: membrane protein, progesterone 21-hydroxylase, benzo(a), pyrene hydroxylase, estradiol 2-hydroxylase, p450, cyp2c5, diclofenac complex, oxidoreductase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• 細胞内の位置: Endoplasmic reticulum membrane (By similarity): P00179
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54989.01

構造登録者

Wester, M.R.,Johnson, E.F.,Stout, C.D. (登録日: 2003-01-23, 公開日: 2003-08-12, 最終更新日: 2023-08-16)

• 主引用文献: WESTER, M.R.,JOHNSON, E.F.,Marques-Soares, C.,Dijols, S.,Dansette, P.M.,Mansuy, D.,STOUT, C.D.; Structure of Mammalian Cytochrome P450 2C5 Complexed with Diclofenac at 2.1 A Resolution: Evidence for an Induced Fit Model of Substrate Binding; Biochemistry, 42:9335-9345, 2003; PubMed: 12899620; DOI: 10.1021/bi034556l

実験手法

X-RAY DIFFRACTION (2.1 Å)