1NQL

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

1NQL の概要

• エントリーDOI: 10.2210/pdb1nql/pdb
• 分子名称: epidermal growth factor receptor, epidermal growth factor, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: cell surface receptor, tyrosine kinase, glycoprotein, endosomal, growth factor, auto-inhibition, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78146.34

構造登録者

Ferguson, K.M.,Lemmon, M.A. (登録日: 2003-01-21, 公開日: 2003-03-11, 最終更新日: 2023-08-16)

• 主引用文献: Ferguson, K.M.,Berger, M.B.,Mendrola, J.M.,Cho, H.,Leahy, D.J.,Lemmon, M.A.; EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization; Mol.Cell, 11:507-517, 2003; PubMed: 12620237; DOI: 10.1016/S1097-2765(03)00047-9

実験手法

X-RAY DIFFRACTION (2.8 Å)