1NQ0

TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

Summary for 1NQ0

Entry DOI	10.2210/pdb1nq0/pdb
Descriptor	Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, ARSENIC, ... (4 entities in total)
Functional Keywords	thyroid hormone receptor, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10828
Total number of polymer chains	1
Total formula weight	30785.84
Authors	Huber, B.R.,Desclozeaux, M.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Baxter, J.D.,Ingraham, H.A.,Fletterick, R.J. (deposition date: 2003-01-20, release date: 2003-04-15, Last modification date: 2024-04-03)
Primary citation	Huber, B.R.,Desclozeaux, M.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Baxter, J.D.,Ingraham, H.A.,Fletterick, R.J. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain Mol.Endocrinol., 17:107-116, 2003 Cited by PubMed: 12511610 DOI: 10.1210/me.2002-0097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation