1NP0

Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline

Summary for 1NP0

• Entry DOI: 10.2210/pdb1np0/pdb
• Related: 1NOU 1NOW
• Descriptor: Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, Beta-hexosaminidase subunit beta chain A, ... (8 entities in total)
• Functional Keywords: (beta/alpha)8-barrel, homodimer, family 20 glycosidase, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 113436.50

Authors

Mark, B.L.,Mahuran, D.J.,Cherney, M.M.,Zhao, D.,Knapp, S.,James, M.N.G. (deposition date: 2003-01-16, release date: 2003-04-29, Last modification date: 2023-08-16)

• Primary citation: Mark, B.L.,Mahuran, D.J.,Cherney, M.M.,Zhao, D.,Knapp, S.,James, M.N.G.; Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease; J.Mol.Biol., 327:1093-1109, 2003; PubMed: 12662933; DOI: 10.1016/S0022-2836(03)00216-X

Experimental method

X-RAY DIFFRACTION (2.5 Å)