1NMK

The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data

Summary for 1NMK

• Entry DOI: 10.2210/pdb1nmk/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase A, (13E,15E)-(3S,6S,9R,10R,11S,12S,18S,21S)-10,12-DIHYDROXY-3-(3-HYDROXYBEN-ZYL)-18-((E)-3-HYDROXY-1-METHYLPROPENYL)-6-ISOPROPYL-11-METHYL-9-(3-OXO-BUTYL)-19-OXA-1,4,7,25-TETRAAZA-BICYCLO[19.3.1]PENTACOSA-13,15-DIENE-2,5,8,20-TETRAONE (3 entities in total)
• Functional Keywords: beta sandwich, cyclophilin-ligand complex, cyclosporin, isomerase, rotamase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P62937
• Total number of polymer chains: 2
• Total formula weight: 37554.77

Authors

Kallen, J.,Sedrani, R.,Wagner, J. (deposition date: 2003-01-10, release date: 2003-04-01, Last modification date: 2023-08-16)

• Primary citation: Sedrani, R.,Kallen, J.,Cabrejas, L.M.M.,Papageorgiou, C.D.,Senia, F.,Rohrbach, S.,Wagner, D.,Thai, B.,Eme, A.-M.J.,France, J.,Oberer, L.,Rihs, G.,Zenke, G.,Wagner, J.; Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data; J.Am.Chem.Soc., 125:3849-3859, 2003; PubMed: 12656618; DOI: 10.1021/ja021327y

Experimental method

X-RAY DIFFRACTION (2.1 Å)