1NC6

Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone

1NC6 の概要

• エントリーDOI: 10.2210/pdb1nc6/pdb
• 分子名称: Trypsinogen, CALCIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor complex, hydrolase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23906.95

構造登録者

Costanzo, M.J.,Yabut, S.C.,Almond Jr., H.R.,Andrade-Gordon, P.,Corcoran, T.W.,de Garavilla, L.,Kauffman, J.A.,Abraham, W.M.,Recacha, R.,Chattopadhyay, D.,Maryanoff, B.E. (登録日: 2002-12-04, 公開日: 2003-09-23, 最終更新日: 2017-10-11)

• 主引用文献: Costanzo, M.J.,Yabut, S.C.,Almond Jr., H.R.,Andrade-Gordon, P.,Corcoran, T.W.,De Garavilla, L.,Kauffman, J.A.,Abraham, W.M.,Recacha, R.,Chattopadhyay, D.,Maryanoff, B.E.; Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone.; J.Med.Chem., 46:3865-3876, 2003; PubMed: 12930148; DOI: 10.1021/jm030050p

実験手法

X-RAY DIFFRACTION (1.9 Å)