1N83

Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

Summary for 1N83

• Entry DOI: 10.2210/pdb1n83/pdb
• Descriptor: Nuclear receptor ROR-alpha, CHOLESTEROL (3 entities in total)
• Functional Keywords: three-layered alpha helical sandwich, receptor, transcription regulation, nuclear protein, dna binding, lipid binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P35398
• Total number of polymer chains: 1
• Total formula weight: 31900.93

Authors

Kallen, J.A.,Schlaeppi, J.M.,Bitsch, F.,Geisse, S.,Geiser, M.,Delhon, I.,Fournier, B. (deposition date: 2002-11-19, release date: 2002-12-11, Last modification date: 2024-02-14)

• Primary citation: Kallen, J.A.,Schlaeppi, J.M.,Bitsch, F.,Geisse, S.,Geiser, M.,Delhon, I.,Fournier, B.; X-ray Structure of hROR(alpha) LBD at 1.63A: Structural and Functional data that Cholesterol or a Cholesterol derivative is the natural ligand of ROR(alpha); Structure, 10:1697-1702, 2002; PubMed: 12467577; DOI: 10.1016/S0969-2126(02)00912-7

Experimental method

X-RAY DIFFRACTION (1.63 Å)