1N83

Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

1N83 の概要

• エントリーDOI: 10.2210/pdb1n83/pdb
• 分子名称: Nuclear receptor ROR-alpha, CHOLESTEROL (3 entities in total)
• 機能のキーワード: three-layered alpha helical sandwich, receptor, transcription regulation, nuclear protein, dna binding, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P35398
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31900.93

構造登録者

Kallen, J.A.,Schlaeppi, J.M.,Bitsch, F.,Geisse, S.,Geiser, M.,Delhon, I.,Fournier, B. (登録日: 2002-11-19, 公開日: 2002-12-11, 最終更新日: 2024-02-14)

• 主引用文献: Kallen, J.A.,Schlaeppi, J.M.,Bitsch, F.,Geisse, S.,Geiser, M.,Delhon, I.,Fournier, B.; X-ray Structure of hROR(alpha) LBD at 1.63A: Structural and Functional data that Cholesterol or a Cholesterol derivative is the natural ligand of ROR(alpha); Structure, 10:1697-1702, 2002; PubMed: 12467577; DOI: 10.1016/S0969-2126(02)00912-7

実験手法

X-RAY DIFFRACTION (1.63 Å)