1N7J

The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor

Summary for 1N7J

• Entry DOI: 10.2210/pdb1n7j/pdb
• Related: 1HNN
• Descriptor: Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, catecholamine, adrenaline, epinephrine, s-adenosylmethionine, s-adenolsylhomocysteine, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 63062.96

Authors

McMillan, F.M.,Archbold, J.,McLeish, M.J.,Caine, J.M.,Criscione, K.R.,Grunewald, G.L.,Martin, J.L. (deposition date: 2002-11-15, release date: 2003-12-23, Last modification date: 2024-02-14)

• Primary citation: McMillan, F.M.,Archbold, J.,McLeish, M.J.,Caine, J.M.,Criscione, K.R.,Grunewald, G.L.,Martin, J.L.; Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.; J.Med.Chem., 47:37-44, 2004; PubMed: 14695818; DOI: 10.1021/jm0205752

Experimental method

X-RAY DIFFRACTION (2.7 Å)