1N64

Crystal structure analysis of the immunodominant antigenic site on Hepatitis C virus protein bound to mAb 19D9D6

1N64 の概要

• エントリーDOI: 10.2210/pdb1n64/pdb
• 分子名称: Fab 19D9D6 light chain, Fab 19D9D6 heavy chain, Genome polyprotein Capsid protein C, ... (4 entities in total)
• 機能のキーワード: antibody peptide complex, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P29846
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49538.41

構造登録者

Menez, R.,Bossus, M.,Muller, B.,Sibai, G.,Dalbon, P.,Ducancel, F.,Jolivet-Reynaud, C.,Stura, E. (登録日: 2002-11-08, 公開日: 2003-02-25, 最終更新日: 2013-09-18)

• 主引用文献: Menez, R.,Bossus, M.,Muller, B.H.,Sibai, G.,Dalbon, P.,Ducancel, F.,Jolivet-Reynaud, C.,Stura, E.A.; Crystal structure of a hydrophobic immunodominant antigenic site on hepatitis C virus core protein complexed to monoclonal antibody 19D9D6.; J.Immunol., 170:1917-1924, 2003; PubMed: 12574359

実験手法

X-RAY DIFFRACTION (2.34 Å)