1MZC

Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a

Summary for 1MZC

• Entry DOI: 10.2210/pdb1mzc/pdb
• Related: 1JCQ 1LD7 1LD8
• Related PRD ID: PRD_900003
• Descriptor: Protein Farnesyltransferase alpha Subunit, Protein Farnesyltransferase beta Subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: alpha-alpha barrel, inhibitor, ftase, pftase, fpp, caax, ras, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 94948.87

Authors

deSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.,Shaw, A.W.,Buser, C.A.,Ellis-Hutchings, M.,Fernandes, C.,Hamilton, K.A.,Huber, H.E.,Kohl, N.E.,Lobell, R.B.,Robinson, R.G.,Tsou, N.N.,Walsh, E.S.,Graham, S.L.,Beese, L.S.,Taylor, J.S. (deposition date: 2002-10-07, release date: 2003-07-08, Last modification date: 2024-02-14)

• Primary citation: DeSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.,Shaw, A.W.,Buser, C.A.,Ellis-Hutchings, M.,Fernandes, C.,Hamilton, K.A.,Huber, H.E.,Kohl, N.E.,Lobell, R.B.,Robinson, R.G.,Tsou, N.N.,Walsh, E.S.,Graham, S.L.,Beese, L.S.,Taylor, J.S.; Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.; J.Med.Chem., 46:2973-2984, 2003; PubMed: 12825937; DOI: 10.1021/jm020587n

Experimental method

X-RAY DIFFRACTION (2 Å)