1MT5

CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE

> Summary

Summary for 1MT5

DescriptorFatty-acid amide hydrolase (E.C.3.1.-.-)
Functional Keywordsamidase signature, hydrolase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationEndoplasmic reticulum membrane; Single-pass membrane protein P97612
Total number of polymer chains16
Total molecular weight949026.66
Authors
Bracey, M.H.,Hanson, M.A.,Masuda, K.R.,Stevens, R.C.,Cravatt, B.F. (deposition date: 2002-09-20, release date: 2002-12-18, modification date: 2009-02-24)
Primary citation
Bracey, M.H.,Hanson, M.A.,Masuda, K.R.,Stevens, R.C.,Cravatt, B.F.
Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling
science, 298:1793-1796, 2002
PubMed: 12459591
DOI: 10.1126/science.1076535
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers31.1%19.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1mt5
no rotation
Molmil generated image of 1mt5
rotated about x axis by 90°
Molmil generated image of 1mt5
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 1mt5
no rotation
Molmil generated image of 1mt5
rotated about x axis by 90°
Molmil generated image of 1mt5
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1mt5.pdb1.gz [174.26 KB])
Coordinate files for Biological unit (1mt5.pdb2.gz [174.9 KB])
Coordinate files for Biological unit (1mt5.pdb3.gz [175.31 KB])
Coordinate files for Biological unit (1mt5.pdb4.gz [174.57 KB])
Coordinate files for Biological unit (1mt5.pdb5.gz [174.47 KB])
Coordinate files for Biological unit (1mt5.pdb6.gz [175.02 KB])
Coordinate files for Biological unit (1mt5.pdb7.gz [175.33 KB])
Coordinate files for Biological unit (1mt5.pdb8.gz [173.49 KB])

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A, B, C, D, E...Fatty-acid amide hydrolasepolymer53758943.716
UniProt (P97612)
Pfam (PF01425)
Rattus norvegicus (Norway rat)@PDBjOleamide hydrolase, Anandamide amidohydrolase
METHYL ARACHIDONYL FLUOROPHOSPHONATEnon-polymer370.516

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains16
Total molecular weight943098.9
Non-Polymers*Number of molecules16
Total molecular weight5927.8
All*Total molecular weight949026.7
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:X-RAY DIFFRACTION (2.8 Å)

Cell axes147.107272.019147.216
Cell angles90.00115.2190.00
SpacegroupP 1 21 1
Resolution limits141.42 - 2.80
the highest resolution shell value2.873 - 2.800
R-factor0.22062
R-work0.21840 (0.20000*)
the highest resolution shell value0.279
R-free0.26228 (0.23700*)
the highest resolution shell value0.350
RMSD bond length0.022 (0.029*)
RMSD bond angle1.587 (1.041*)

Data Collection Statistics

Resolution limits50.00 - 2.80
the highest resolution shell value -
Number of reflections173615
Rmerge_l_obs0.104*
the highest resolution shell value0.264*
Completeness76.0*
the highest resolution shell value79.*
Redundancy2.1*
I/sigma(I)2

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit
1VAPOR DIFFUSION, HANGING DROP5293unknown*

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
11dropprotein8 (mg/ml)
21reservoirsodium citrate100 (mM)pH5.
31reservoirlithium sulfate100 (mM)
41reservoirPEG60007 (%(w/v))
51reservoirMPD5 (%(v/v))
61reservoirdithiothreitol0-20 (mM)
Annotated Information is extracted from Literature Info*

> Functional details

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005789cellular_componentendoplasmic reticulum membrane
A0000139cellular_componentGolgi membrane
A0016021cellular_componentintegral component of membrane
A0031090cellular_componentorganelle membrane
A0004040molecular_functionamidase activity
A0103073molecular_functionanandamide amidohydrolase activity
A0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
A0017064molecular_functionfatty acid amide hydrolase activity
A0016788molecular_functionhydrolase activity, acting on ester bonds
A0008289molecular_functionlipid binding
A0005543molecular_functionphospholipid binding
A0042803molecular_functionprotein homodimerization activity
A0009062biological_processfatty acid catabolic process
A0006631biological_processfatty acid metabolic process
B0005789cellular_componentendoplasmic reticulum membrane
B0000139cellular_componentGolgi membrane
B0016021cellular_componentintegral component of membrane
B0031090cellular_componentorganelle membrane
B0004040molecular_functionamidase activity
B0103073molecular_functionanandamide amidohydrolase activity
B0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
B0017064molecular_functionfatty acid amide hydrolase activity
B0016788molecular_functionhydrolase activity, acting on ester bonds
B0008289molecular_functionlipid binding
B0005543molecular_functionphospholipid binding
B0042803molecular_functionprotein homodimerization activity
B0009062biological_processfatty acid catabolic process
B0006631biological_processfatty acid metabolic process
C0005789cellular_componentendoplasmic reticulum membrane
C0000139cellular_componentGolgi membrane
C0016021cellular_componentintegral component of membrane
C0031090cellular_componentorganelle membrane
C0004040molecular_functionamidase activity
C0103073molecular_functionanandamide amidohydrolase activity
C0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
C0017064molecular_functionfatty acid amide hydrolase activity
C0016788molecular_functionhydrolase activity, acting on ester bonds
C0008289molecular_functionlipid binding
C0005543molecular_functionphospholipid binding
C0042803molecular_functionprotein homodimerization activity
C0009062biological_processfatty acid catabolic process
C0006631biological_processfatty acid metabolic process
D0005789cellular_componentendoplasmic reticulum membrane
D0000139cellular_componentGolgi membrane
D0016021cellular_componentintegral component of membrane
D0031090cellular_componentorganelle membrane
D0004040molecular_functionamidase activity
D0103073molecular_functionanandamide amidohydrolase activity
D0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
D0017064molecular_functionfatty acid amide hydrolase activity
D0016788molecular_functionhydrolase activity, acting on ester bonds
D0008289molecular_functionlipid binding
D0005543molecular_functionphospholipid binding
D0042803molecular_functionprotein homodimerization activity
D0009062biological_processfatty acid catabolic process
D0006631biological_processfatty acid metabolic process
E0005789cellular_componentendoplasmic reticulum membrane
E0000139cellular_componentGolgi membrane
E0016021cellular_componentintegral component of membrane
E0031090cellular_componentorganelle membrane
E0004040molecular_functionamidase activity
E0103073molecular_functionanandamide amidohydrolase activity
E0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
E0017064molecular_functionfatty acid amide hydrolase activity
E0016788molecular_functionhydrolase activity, acting on ester bonds
E0008289molecular_functionlipid binding
E0005543molecular_functionphospholipid binding
E0042803molecular_functionprotein homodimerization activity
E0009062biological_processfatty acid catabolic process
E0006631biological_processfatty acid metabolic process
F0005789cellular_componentendoplasmic reticulum membrane
F0000139cellular_componentGolgi membrane
F0016021cellular_componentintegral component of membrane
F0031090cellular_componentorganelle membrane
F0004040molecular_functionamidase activity
F0103073molecular_functionanandamide amidohydrolase activity
F0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
F0017064molecular_functionfatty acid amide hydrolase activity
F0016788molecular_functionhydrolase activity, acting on ester bonds
F0008289molecular_functionlipid binding
F0005543molecular_functionphospholipid binding
F0042803molecular_functionprotein homodimerization activity
F0009062biological_processfatty acid catabolic process
F0006631biological_processfatty acid metabolic process
G0005789cellular_componentendoplasmic reticulum membrane
G0000139cellular_componentGolgi membrane
G0016021cellular_componentintegral component of membrane
G0031090cellular_componentorganelle membrane
G0004040molecular_functionamidase activity
G0103073molecular_functionanandamide amidohydrolase activity
G0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
G0017064molecular_functionfatty acid amide hydrolase activity
G0016788molecular_functionhydrolase activity, acting on ester bonds
G0008289molecular_functionlipid binding
G0005543molecular_functionphospholipid binding
G0042803molecular_functionprotein homodimerization activity
G0009062biological_processfatty acid catabolic process
G0006631biological_processfatty acid metabolic process
H0005789cellular_componentendoplasmic reticulum membrane
H0000139cellular_componentGolgi membrane
H0016021cellular_componentintegral component of membrane
H0031090cellular_componentorganelle membrane
H0004040molecular_functionamidase activity
H0103073molecular_functionanandamide amidohydrolase activity
H0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
H0017064molecular_functionfatty acid amide hydrolase activity
H0016788molecular_functionhydrolase activity, acting on ester bonds
H0008289molecular_functionlipid binding
H0005543molecular_functionphospholipid binding
H0042803molecular_functionprotein homodimerization activity
H0009062biological_processfatty acid catabolic process
H0006631biological_processfatty acid metabolic process
I0005789cellular_componentendoplasmic reticulum membrane
I0000139cellular_componentGolgi membrane
I0016021cellular_componentintegral component of membrane
I0031090cellular_componentorganelle membrane
I0004040molecular_functionamidase activity
I0103073molecular_functionanandamide amidohydrolase activity
I0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
I0017064molecular_functionfatty acid amide hydrolase activity
I0016788molecular_functionhydrolase activity, acting on ester bonds
I0008289molecular_functionlipid binding
I0005543molecular_functionphospholipid binding
I0042803molecular_functionprotein homodimerization activity
I0009062biological_processfatty acid catabolic process
I0006631biological_processfatty acid metabolic process
J0005789cellular_componentendoplasmic reticulum membrane
J0000139cellular_componentGolgi membrane
J0016021cellular_componentintegral component of membrane
J0031090cellular_componentorganelle membrane
J0004040molecular_functionamidase activity
J0103073molecular_functionanandamide amidohydrolase activity
J0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
J0017064molecular_functionfatty acid amide hydrolase activity
J0016788molecular_functionhydrolase activity, acting on ester bonds
J0008289molecular_functionlipid binding
J0005543molecular_functionphospholipid binding
J0042803molecular_functionprotein homodimerization activity
J0009062biological_processfatty acid catabolic process
J0006631biological_processfatty acid metabolic process
K0005789cellular_componentendoplasmic reticulum membrane
K0000139cellular_componentGolgi membrane
K0016021cellular_componentintegral component of membrane
K0031090cellular_componentorganelle membrane
K0004040molecular_functionamidase activity
K0103073molecular_functionanandamide amidohydrolase activity
K0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
K0017064molecular_functionfatty acid amide hydrolase activity
K0016788molecular_functionhydrolase activity, acting on ester bonds
K0008289molecular_functionlipid binding
K0005543molecular_functionphospholipid binding
K0042803molecular_functionprotein homodimerization activity
K0009062biological_processfatty acid catabolic process
K0006631biological_processfatty acid metabolic process
L0005789cellular_componentendoplasmic reticulum membrane
L0000139cellular_componentGolgi membrane
L0016021cellular_componentintegral component of membrane
L0031090cellular_componentorganelle membrane
L0004040molecular_functionamidase activity
L0103073molecular_functionanandamide amidohydrolase activity
L0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
L0017064molecular_functionfatty acid amide hydrolase activity
L0016788molecular_functionhydrolase activity, acting on ester bonds
L0008289molecular_functionlipid binding
L0005543molecular_functionphospholipid binding
L0042803molecular_functionprotein homodimerization activity
L0009062biological_processfatty acid catabolic process
L0006631biological_processfatty acid metabolic process
M0005789cellular_componentendoplasmic reticulum membrane
M0000139cellular_componentGolgi membrane
M0016021cellular_componentintegral component of membrane
M0031090cellular_componentorganelle membrane
M0004040molecular_functionamidase activity
M0103073molecular_functionanandamide amidohydrolase activity
M0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
M0017064molecular_functionfatty acid amide hydrolase activity
M0016788molecular_functionhydrolase activity, acting on ester bonds
M0008289molecular_functionlipid binding
M0005543molecular_functionphospholipid binding
M0042803molecular_functionprotein homodimerization activity
M0009062biological_processfatty acid catabolic process
M0006631biological_processfatty acid metabolic process
N0005789cellular_componentendoplasmic reticulum membrane
N0000139cellular_componentGolgi membrane
N0016021cellular_componentintegral component of membrane
N0031090cellular_componentorganelle membrane
N0004040molecular_functionamidase activity
N0103073molecular_functionanandamide amidohydrolase activity
N0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
N0017064molecular_functionfatty acid amide hydrolase activity
N0016788molecular_functionhydrolase activity, acting on ester bonds
N0008289molecular_functionlipid binding
N0005543molecular_functionphospholipid binding
N0042803molecular_functionprotein homodimerization activity
N0009062biological_processfatty acid catabolic process
N0006631biological_processfatty acid metabolic process
O0005789cellular_componentendoplasmic reticulum membrane
O0000139cellular_componentGolgi membrane
O0016021cellular_componentintegral component of membrane
O0031090cellular_componentorganelle membrane
O0004040molecular_functionamidase activity
O0103073molecular_functionanandamide amidohydrolase activity
O0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
O0017064molecular_functionfatty acid amide hydrolase activity
O0016788molecular_functionhydrolase activity, acting on ester bonds
O0008289molecular_functionlipid binding
O0005543molecular_functionphospholipid binding
O0042803molecular_functionprotein homodimerization activity
O0009062biological_processfatty acid catabolic process
O0006631biological_processfatty acid metabolic process
P0005789cellular_componentendoplasmic reticulum membrane
P0000139cellular_componentGolgi membrane
P0016021cellular_componentintegral component of membrane
P0031090cellular_componentorganelle membrane
P0004040molecular_functionamidase activity
P0103073molecular_functionanandamide amidohydrolase activity
P0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
P0017064molecular_functionfatty acid amide hydrolase activity
P0016788molecular_functionhydrolase activity, acting on ester bonds
P0008289molecular_functionlipid binding
P0005543molecular_functionphospholipid binding
P0042803molecular_functionprotein homodimerization activity
P0009062biological_processfatty acid catabolic process
P0006631biological_processfatty acid metabolic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC115BINDING SITE FOR RESIDUE MAY A 600
ChainResidue
AMET155
ASER157
ASER181
AASP201
AILE202
AGLY203
AGLY204
ASER205
ATYR299
ALEU336
AALA341
APHE345
AARG392
AILE455
AVAL459

AC214BINDING SITE FOR RESIDUE MAY B 600
ChainResidue
BMET155
BLEU156
BSER157
BSER181
BASP201
BILE202
BGLY203
BGLY204
BSER205
BTYR299
BLEU336
BALA341
BPHE345
BILE455

AC317BINDING SITE FOR RESIDUE MAY C 600
ChainResidue
CMET155
CLEU156
CSER157
CPHE158
CSER181
CASP201
CILE202
CGLY203
CGLY204
CSER205
CTYR299
CLEU336
CALA341
CLEU344
CPHE345
CILE455
CVAL459

AC416BINDING SITE FOR RESIDUE MAY D 600
ChainResidue
DMET155
DSER157
DSER181
DASP201
DILE202
DGLY203
DGLY204
DSER205
DTYR299
DLEU336
DALA341
DLEU344
DPHE345
DPHE396
DILE455
DVAL459

AC516BINDING SITE FOR RESIDUE MAY E 600
ChainResidue
EMET155
ELEU156
ESER157
ESER181
EASP201
EILE202
EGLY203
EGLY204
ESER205
ETYR299
ELEU336
EALA341
ELEU344
EPHE345
EILE455
EVAL459

AC615BINDING SITE FOR RESIDUE MAY F 600
ChainResidue
FMET155
FSER157
FSER181
FASP201
FILE202
FGLY203
FGLY204
FSER205
FTYR299
FLEU336
FALA341
FLEU344
FPHE345
FILE455
FVAL459

AC714BINDING SITE FOR RESIDUE MAY G 600
ChainResidue
GMET155
GSER157
GPHE158
GSER181
GASP201
GILE202
GGLY203
GGLY204
GSER205
GTYR299
GLEU336
GPHE345
GILE455
GVAL459

AC815BINDING SITE FOR RESIDUE MAY H 600
ChainResidue
HMET155
HSER157
HSER181
HASP201
HILE202
HGLY203
HGLY204
HSER205
HTYR299
HLEU336
HALA341
HLEU344
HPHE345
HILE455
HVAL459

AC915BINDING SITE FOR RESIDUE MAY I 600
ChainResidue
IMET155
ISER157
IPHE158
ISER181
IASP201
IILE202
IGLY203
ISER205
ITYR299
ILEU336
IALA341
ILEU344
IPHE345
IILE455
IVAL459

BC116BINDING SITE FOR RESIDUE MAY J 600
ChainResidue
JMET155
JSER157
JPHE158
JSER181
JASP201
JILE202
JGLY203
JGLY204
JSER205
JTYR299
JLEU336
JALA341
JLEU344
JPHE345
JILE455
JTRP495

BC216BINDING SITE FOR RESIDUE MAY K 600
ChainResidue
KMET155
KLEU156
KSER157
KSER181
KASP201
KILE202
KGLY203
KGLY204
KSER205
KTYR299
KLEU336
KALA341
KLEU344
KPHE345
KILE455
KVAL459

BC316BINDING SITE FOR RESIDUE MAY L 600
ChainResidue
LMET155
LLEU156
LSER157
LPHE158
LSER181
LASP201
LILE202
LGLY203
LSER205
LTYR299
LLEU336
LPHE345
LARG392
LILE455
LVAL459
LTRP495

BC418BINDING SITE FOR RESIDUE MAY M 600
ChainResidue
MMET155
MLEU156
MSER157
MSER181
MTHR200
MASP201
MILE202
MGLY203
MGLY204
MSER205
MTYR299
MLEU336
MPHE345
MLEU368
MPHE396
MTHR452
MILE455
MVAL459

BC516BINDING SITE FOR RESIDUE MAY N 600
ChainResidue
NMET155
NLEU156
NSER157
NPHE158
NSER181
NASP201
NILE202
NGLY203
NGLY204
NSER205
NTYR299
NLEU336
NALA341
NPHE345
NPHE396
NILE455

BC616BINDING SITE FOR RESIDUE MAY O 600
ChainResidue
OMET155
OLEU156
OSER157
OSER181
OASP201
OILE202
OGLY203
OGLY204
OSER205
OTYR299
OLEU336
OALA341
OPHE345
OILE455
OVAL459
OTRP495

BC716BINDING SITE FOR RESIDUE MAY P 600
ChainResidue
PMET155
PLEU156
PSER157
PSER181
PASP201
PILE202
PGLY203
PGLY204
PSER205
PTYR299
PLEU336
PLEU344
PPHE345
PARG392
PILE455
PTRP495

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
MAY_1mt5_A_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
ALYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
AMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
AGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ATHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ATYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ALEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ASER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ALEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ALEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
AARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
AALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ATHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
AILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
AVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ATRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_B_60030METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
BLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
BTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_C_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
CLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CSER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
CTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_D_60031METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
DLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DILE491-SER492MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
DTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_E_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
ELYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
EMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
EGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ETHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ETYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ELEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ESER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ELEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ELEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
EARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
EALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ETHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
EILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
EVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ETRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_F_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
FLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
FTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_G_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
GLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GSER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
GTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_H_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
HLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
HTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_I_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
ILYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
IMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
IGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ITHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ITYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ILEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ISER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ILEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ILEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
IARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
IALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ITHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
IILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
IVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
ITRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_J_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
JLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
JTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_K_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
KLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
KTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_L_60030METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
LLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
LTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_M_60031METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
MLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MPRO484MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
MTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_N_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
NLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
NTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_O_60030METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
OLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OGLY216-SER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OPHE244MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
OTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

MAY_1mt5_P_60029METHYL ARACHIDONYL FLUOROPHOSPHONATE binding site
ChainResidueligand
PLYS142MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PMET191-PHE194MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PSER217MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PTHR236-SER241MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PLEU278MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PTYR335MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PLEU372-GLU373MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PSER376-ALA377MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PLEU380-PHE381MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PLEU404MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PARG428MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PALA431-PHE432MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PTHR488-GLY489MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PILE491MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PVAL495MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE
PTRP531MAY: METHYL ARACHIDONYL FLUOROPHOSPHONATE

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0057116Amidases signature. G-[GAV]-S-[GS](2)-G-x-[GSAE]-[GSAVYCT]-x-[LIVMT]-[GSA]-x(6)-[GSAT]-x
ChainResidueDetails
ANA*
BNA*
CNA*
DNA*
ENA*
FNA*
GNA*
HNA*
INA*
JNA*
KNA*
LNA*
MNA*
NNA*
ONA*
PNA*

?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12Charge relay system.
ChainResidueDetails
ALYS106
ASER181

SWS_FT_FI21Acyl-ester intermediate.
ChainResidueDetails
ASER205

SWS_FT_FI31Substrate; via carbonyl oxygen.
ChainResidueDetails
AMET155

SWS_FT_FI41Substrate.
ChainResidueDetails
ASER181

SWS_FT_FI62Charge relay system.
ChainResidueDetails
BLYS106
BSER181

SWS_FT_FI71Acyl-ester intermediate.
ChainResidueDetails
BSER205

SWS_FT_FI81Substrate; via carbonyl oxygen.
ChainResidueDetails
BMET155

SWS_FT_FI91Substrate.
ChainResidueDetails
BSER181

SWS_FT_FI112Charge relay system.
ChainResidueDetails
CLYS106
CSER181

SWS_FT_FI121Acyl-ester intermediate.
ChainResidueDetails
CSER205

SWS_FT_FI131Substrate; via carbonyl oxygen.
ChainResidueDetails
CMET155

SWS_FT_FI141Substrate.
ChainResidueDetails
CSER181

SWS_FT_FI162Charge relay system.
ChainResidueDetails
DLYS106
DSER181

SWS_FT_FI171Acyl-ester intermediate.
ChainResidueDetails
DSER205

SWS_FT_FI181Substrate; via carbonyl oxygen.
ChainResidueDetails
DMET155

SWS_FT_FI191Substrate.
ChainResidueDetails
DSER181

SWS_FT_FI212Charge relay system.
ChainResidueDetails
ELYS106
ESER181

SWS_FT_FI221Acyl-ester intermediate.
ChainResidueDetails
ESER205

SWS_FT_FI231Substrate; via carbonyl oxygen.
ChainResidueDetails
EMET155

SWS_FT_FI241Substrate.
ChainResidueDetails
ESER181

SWS_FT_FI262Charge relay system.
ChainResidueDetails
FLYS106
FSER181

SWS_FT_FI271Acyl-ester intermediate.
ChainResidueDetails
FSER205

SWS_FT_FI281Substrate; via carbonyl oxygen.
ChainResidueDetails
FMET155

SWS_FT_FI291Substrate.
ChainResidueDetails
FSER181

SWS_FT_FI312Charge relay system.
ChainResidueDetails
GLYS106
GSER181

SWS_FT_FI321Acyl-ester intermediate.
ChainResidueDetails
GSER205

SWS_FT_FI331Substrate; via carbonyl oxygen.
ChainResidueDetails
GMET155

SWS_FT_FI341Substrate.
ChainResidueDetails
GSER181

SWS_FT_FI362Charge relay system.
ChainResidueDetails
HLYS106
HSER181

SWS_FT_FI371Acyl-ester intermediate.
ChainResidueDetails
HSER205

SWS_FT_FI381Substrate; via carbonyl oxygen.
ChainResidueDetails
HMET155

SWS_FT_FI391Substrate.
ChainResidueDetails
HSER181

SWS_FT_FI412Charge relay system.
ChainResidueDetails
ILYS106
ISER181

SWS_FT_FI421Acyl-ester intermediate.
ChainResidueDetails
ISER205

SWS_FT_FI431Substrate; via carbonyl oxygen.
ChainResidueDetails
IMET155

SWS_FT_FI441Substrate.
ChainResidueDetails
ISER181

SWS_FT_FI462Charge relay system.
ChainResidueDetails
JLYS106
JSER181

SWS_FT_FI471Acyl-ester intermediate.
ChainResidueDetails
JSER205

SWS_FT_FI481Substrate; via carbonyl oxygen.
ChainResidueDetails
JMET155

SWS_FT_FI491Substrate.
ChainResidueDetails
JSER181

SWS_FT_FI512Charge relay system.
ChainResidueDetails
KLYS106
KSER181

SWS_FT_FI521Acyl-ester intermediate.
ChainResidueDetails
KSER205

SWS_FT_FI531Substrate; via carbonyl oxygen.
ChainResidueDetails
KMET155

SWS_FT_FI541Substrate.
ChainResidueDetails
KSER181

SWS_FT_FI562Charge relay system.
ChainResidueDetails
LLYS106
LSER181

SWS_FT_FI571Acyl-ester intermediate.
ChainResidueDetails
LSER205

SWS_FT_FI581Substrate; via carbonyl oxygen.
ChainResidueDetails
LMET155

SWS_FT_FI591Substrate.
ChainResidueDetails
LSER181

SWS_FT_FI612Charge relay system.
ChainResidueDetails
MLYS106
MSER181

SWS_FT_FI621Acyl-ester intermediate.
ChainResidueDetails
MSER205

SWS_FT_FI631Substrate; via carbonyl oxygen.
ChainResidueDetails
MMET155

SWS_FT_FI641Substrate.
ChainResidueDetails
MSER181

SWS_FT_FI662Charge relay system.
ChainResidueDetails
NLYS106
NSER181

SWS_FT_FI671Acyl-ester intermediate.
ChainResidueDetails
NSER205

SWS_FT_FI681Substrate; via carbonyl oxygen.
ChainResidueDetails
NMET155

SWS_FT_FI691Substrate.
ChainResidueDetails
NSER181

SWS_FT_FI712Charge relay system.
ChainResidueDetails
OLYS106
OSER181

SWS_FT_FI721Acyl-ester intermediate.
ChainResidueDetails
OSER205

SWS_FT_FI731Substrate; via carbonyl oxygen.
ChainResidueDetails
OMET155

SWS_FT_FI741Substrate.
ChainResidueDetails
OSER181

SWS_FT_FI762Charge relay system.
ChainResidueDetails
PLYS106
PSER181

SWS_FT_FI771Acyl-ester intermediate.
ChainResidueDetails
PSER205

SWS_FT_FI781Substrate; via carbonyl oxygen.
ChainResidueDetails
PMET155

SWS_FT_FI791Substrate.
ChainResidueDetails
PSER181

?

Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA14
ChainResidueDetails
ALYS142
ASER218
AILE238
ASER241

?

Catalytic Information from CATRES

site_idNumber of ResiduesDetails

> Sequence Neighbor

> Downloads

Resources

File formatFile name (file size)
PDBallpdb1mt5.ent.gz (1.27 MB)
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all (no-compress)pdb1mt5.ent (5.24 MB)
header onlypdb1mt5.ent.gz (27.12 KB)
Display
PDBx/mmCIF1mt5.cif.gz (1.53 MB)
PDBMLall1mt5.xml.gz (2.4 MB)
no-atom1mt5-noatom.xml.gz (236.03 KB)
Display
ext-atom1mt5-extatom.xml.gz (1.47 MB)
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PDBMLplusall1mt5-plus.xml.gz (2.4 MB)
no-atom1mt5-plus-noatom.xml.gz (244.71 KB)
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add only1mt5-add.xml.gz (8.68 KB)
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RDF1mt5.rdf.gz (471.16 KB)
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Biological unit (PDB format)1mt5.pdb1.gz (174.26 KB) (A,B)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb2.gz (174.9 KB) (C,D)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb3.gz (175.31 KB) (E,F)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb4.gz (174.57 KB) (G,H)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb5.gz (174.47 KB) (I,J)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb6.gz (175.02 KB) (K,L)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb7.gz (175.33 KB) (M,N)
*author and software defined assembly, 2 molecule(s) (dimeric)
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1mt5.pdb8.gz (173.49 KB) (O,P)
*author and software defined assembly, 2 molecule(s) (dimeric)
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Validation reportsPDF1mt5​_validation.pdf.gz (351.69 KB)
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PDF-full1mt5​_full​_validation.pdf.gz (502.73 KB)
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XML1mt5​_validation.xml.gz (168.47 KB)
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PNG1mt5​_multipercentile​_validation.png.gz (119.77 KB)
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SVG1mt5​_multipercentile​_validation.svg.gz (816 B)
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Sequence (fasta)1mt5​_seq.txt
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