1MMK

Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase ((FeII)) complexed with tetrahydrobiopterin and thienylalanine

1MMK の概要

• エントリーDOI: 10.2210/pdb1mmk/pdb
• 関連するPDBエントリー: 1J8T 1J8U 1KW0 1MMT
• 分子名称: Phenylalanine-4-hydroxylase, FE (II) ION, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: basket-arrangement, 13 alpha-helices, 8 beta-strands, ferrous iron, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38165.94

構造登録者

Andersen, O.A.,Flatmark, T.,Hough, E. (登録日: 2002-09-04, 公開日: 2003-09-04, 最終更新日: 2023-10-25)

• 主引用文献: Andersen, O.A.,Stokka, A.J.,Flatmark, T.,Hough, E.; 2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding; J.Mol.Biol., 333:747-757, 2003; PubMed: 14568534; DOI: 10.1016/j.jmb.2003.09.004

実験手法

X-RAY DIFFRACTION (2 Å)