1MLW

Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)

1MLW の概要

• エントリーDOI: 10.2210/pdb1mlw/pdb
• 分子名称: Tryptophan 5-monooxygenase, FE (III) ION, 7,8-DIHYDROBIOPTERIN, ... (4 entities in total)
• 機能のキーワード: aromatic amino acid hydroxylase catalytic domain fold, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34936.60

構造登録者

Wang, L.,Erlandsen, H.,Haavik, J.,Knappskog, P.M.,Stevens, R.C. (登録日: 2002-08-31, 公開日: 2002-12-18, 最終更新日: 2024-02-14)

• 主引用文献: Wang, L.,Erlandsen, H.,Haavik, J.,Knappskog, P.M.,Stevens, R.C.; Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin; Biochemistry, 41:12569-12574, 2002; PubMed: 12379098; DOI: 10.1021/bi026561f

実験手法

X-RAY DIFFRACTION (1.71 Å)