1MLW

Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)

Summary for 1MLW

Entry DOI	10.2210/pdb1mlw/pdb
Descriptor	Tryptophan 5-monooxygenase, FE (III) ION, 7,8-DIHYDROBIOPTERIN, ... (4 entities in total)
Functional Keywords	aromatic amino acid hydroxylase catalytic domain fold, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34936.60
Authors	Wang, L.,Erlandsen, H.,Haavik, J.,Knappskog, P.M.,Stevens, R.C. (deposition date: 2002-08-31, release date: 2002-12-18, Last modification date: 2024-02-14)
Primary citation	Wang, L.,Erlandsen, H.,Haavik, J.,Knappskog, P.M.,Stevens, R.C. Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry, 41:12569-12574, 2002 Cited by PubMed: 12379098 DOI: 10.1021/bi026561f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation