1MKW

THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING

1MKW の概要

• エントリーDOI: 10.2210/pdb1mkw/pdb
• 分子名称: ALPHA-THROMBIN, PRETHROMBIN-2, ... (4 entities in total)
• 機能のキーワード: complex (blood coagulation-proenzyme), thrombin, prethrombin-2, plasma, serine protease, complex (blood coagulation-proenzyme) complex, complex (blood coagulation/proenzyme)
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Secreted, extracellular space: P00735 P00735 P00735
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70997.29

構造登録者

Malkowski, M.G.,Edwards, B.F.P. (登録日: 1997-03-13, 公開日: 1997-07-07, 最終更新日: 2011-07-13)

• 主引用文献: Malkowski, M.G.,Martin, P.D.,Guzik, J.C.,Edwards, B.F.; The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.; Protein Sci., 6:1438-1448, 1997; PubMed: 9232645

実験手法

X-RAY DIFFRACTION (2.3 Å)