1MFP

E. coli Enoyl Reductase in complex with NAD and SB611113

Summary for 1MFP

• Entry DOI: 10.2210/pdb1mfp/pdb
• Related: 1C14 1I2Z 1I30
• Descriptor: enoyl-[acyl-carrier-protein] reductase [Nadh], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (E)-N-METHYL-N-(1-METHYL-1H-INDOL-3-YLMETHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-3-YL)-ACRYLAMIDE, ... (5 entities in total)
• Functional Keywords: fabi, enoyl reductase, enoyl-acp reductase, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57957.64

Authors

Seefeld, M.A.,Miller, W.H.,Newlander, K.A.,Burgess, W.J.,DeWolf Jr., W.E.,Elkins, P.A.,Head, M.S.,Jakas, D.R.,Janson, C.A.,Keller, P.M.,Manley, P.J.,Moore, T.D.,Payne, D.J.,Pearson, S.,Polizzi, B.J.,Qiu, X.,Rittenhouse, S.F.,Uzinskas, I.N.,Wallis, N.G.,Huffman, W.F. (deposition date: 2002-08-13, release date: 2003-05-06, Last modification date: 2024-02-14)

• Primary citation: Seefeld, M.A.,Miller, W.H.,Newlander, K.A.,Burgess, W.J.,DeWolf Jr., W.E.,Elkins, P.A.,Head, M.S.,Jakas, D.R.,Janson, C.A.,Keller, P.M.,Manley, P.J.,Moore, T.D.,Payne, D.J.,Pearson, S.,Polizzi, B.J.,Qiu, X.,Rittenhouse, S.F.,Uzinskas, I.N.,Wallis, N.G.,Huffman, W.F.; Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK; J.MED.CHEM., 46:1627-1635, 2003; PubMed: 12699381; DOI: 10.1021/jm0204035

Experimental method

X-RAY DIFFRACTION (2.33 Å)