1M54

CYSTATHIONINE-BETA SYNTHASE: REDUCED VICINAL THIOLS

Summary for 1M54

• Entry DOI: 10.2210/pdb1m54/pdb
• Related: 1JBQ
• Descriptor: CYSTATHIONINE BETA-SYNTHASE, PYRIDOXAL-5'-PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• Functional Keywords: plp protein fold type ii (tryptophan synthase), plp and heme bound to protein, reduced vicinal cysteines, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P35520
• Total number of polymer chains: 6
• Total formula weight: 244718.14

Authors

Taoka, S.,Lepore, B.W.,Kabil, O.,Ojha, S.,Ringe, D.,Banerjee, R. (deposition date: 2002-07-08, release date: 2002-08-14, Last modification date: 2021-10-27)

• Primary citation: Taoka, S.,Lepore, B.W.,Kabil, O.,Ojha, S.,Ringe, D.,Banerjee, R.; HUMAN CYSTATHIONINE BETA-SYNTHASE IS A HEME SENSOR PROTEIN. EVIDENCE THAT THE REDOX SENSOR IS HEME AND NOT THE VICINAL CYSTEINES IN THE CXXC MOTIF SEEN IN THE CRYSTAL STRUCTURE OF THE TRUNCATED ENZYME; BIOCHEMISTRY, 41:10454-10461, 2002; PubMed: 12173932; DOI: 10.1021/bi026052d

Experimental method

X-RAY DIFFRACTION (2.9 Å)